In vitro activity of the oxazolidinone RWJ-416457 against linezolid-resistant and -susceptible staphylococci and enterococci.
نویسندگان
چکیده
RWJ-416457, a novel oxazolidinone, had modal MICs of 0.5 to 1 microg/ml for linezolid-susceptible staphylococci and enterococci, versus linezolid MICs for these organisms of 1 or 2 microg/ml. RWJ-416457 MICs for mutants with 23S rRNA mutations were 2 to 32 microg/ml, versus linezolid MICs of 8 to 64 microg/ml; actual values reflected the proportion of gene copies mutated.
منابع مشابه
In vivo activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457.
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عنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 51 3 شماره
صفحات -
تاریخ انتشار 2007